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The clinicopathological characteristics of gastric cancer and precancerous conditions in gastric DLBCL and MALT lymphoma patients: a multi-center retrospective study.
Feng, Yun; Duan, Tian-Jiao; Huang, Qing; Li, Zhi-Yi; Liu, Ya-Ping; Luo, Miao-Sha; Lu, Gui-Fang; Shi, Wen; Zhang, Zhi-Yong; Li, Hong-Xia.
Affiliation
  • Feng Y; The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
  • Duan TJ; Department of Gastroenterology, Shaanxi Provincial People's Hospital, Xi'an, People's Republic of China.
  • Huang Q; Department of Gastroenterology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People's Republic of China.
  • Li ZY; Department of Hematology, The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
  • Liu YP; The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
  • Luo MS; The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
  • Lu GF; The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
  • Shi W; The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
  • Zhang ZY; The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
  • Li HX; The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
Ann Med ; 55(1): 2193423, 2023 12.
Article in En | MEDLINE | ID: mdl-37183786
OBJECTIVE: The objective of this study is to explore the clinicopathological characteristics of gastric cancer and precancerous conditions in patients with primary gastric lymphoma. METHODS: We analyzed 474 cases of primary gastric lymphoma, mainly DLBCL and MALT, from three clinical centres retrospectively, and compared the clinicopathological parameters of primary gastric lymphoma patients complicated with gastric cancer, precancerous conditions, or with no complications. RESULTS: A total of 5.1% of the patients with primary gastric lymphoma were diagnosed with gastric cancer, including metachronous gastric adenocarcinoma (3.2%) and synchronous gastric adenocarcinoma (1.9%). Of the patients with gastric lymphoma, 14.6% had precancerous conditions including atrophy (14.6%), intestinal metaplasia (8.9%), and low-grade intraepithelial neoplasia (1.9%). Primary gastric lymphoma patients with an ulcerative type (p = 0.009) and Lugano classification stage IIE + IV (p < 0.001) lymphoma had a higher risk of complicating with gastric cancers or precancerous conditions. The rate of infection of Helicobacter pylori (Hp) was 68.4% in patients with primary gastric lymphoma, which was higher in patients with MALT lymphoma (p < 0.001), Lugano classification stage I + II (p < 0.001), and patients complicated with precancerous conditions and gastric cancer (p < 0.001), especially gastric cancer of the intestinal type (p = 0.04). Gastric cancer (95.8%) and precancerous conditions (91.3%) occurred mostly in Hp-infected primary gastric lymphoma patients, with a minor subset of Hp-eradicated patients. Primary gastric lymphoma patients had a higher detection rate of early gastric cancer (25.0%) and a five-year survival rate (40.0%) than the general Chinese population. CONCLUSIONS: Patients with primary gastric lymphoma have a high risk of developing gastric cancer and precancerous conditions, and this risk may be related to Helicobacter pylori infection. Follow-up of primary gastric lymphoma provides an opportunity for the detection of early gastric cancer.Key messages5.1% of the patients with primary gastric lymphoma were diagnosed with gastric cancer.14.6% of the patients with gastric lymphoma had premalignant lesions including atrophy (14.6%), intestinal metaplasia (8.9%), and low-grade intraepithelial neoplasia (1.9%).Primary gastric lymphoma patients complicating with gastric cancer had a higher infection rate of Helicobacter pylori (100.0%), a detection rate of early gastric cancer (25.0%) and a five-year survival rate (40.0%) than the general Chinese population.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precancerous Conditions / Stomach Neoplasms / Adenocarcinoma / Helicobacter pylori / Helicobacter Infections / Lymphoma, B-Cell, Marginal Zone Type of study: Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: Ann Med Journal subject: MEDICINA Year: 2023 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precancerous Conditions / Stomach Neoplasms / Adenocarcinoma / Helicobacter pylori / Helicobacter Infections / Lymphoma, B-Cell, Marginal Zone Type of study: Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: Ann Med Journal subject: MEDICINA Year: 2023 Document type: Article Country of publication: